Mechanisms Cancer Immunotherapy In Vitro via Multiple Sensitizes Tumor Cells to Antibody-Based Targeting Neural-Restrictive Silencer Factor
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Targeting neural-restrictive silencer factor sensitizes tumor cells to antibody-based cancer immunotherapy in vitro via multiple mechanisms.
Tumor cells escape clearance by complement by abundantly expressing CD59 and other membrane complement regulators. Recently, we designed a peptide derived from the neural-restrictive silencer factor (REST), REST68, which we showed to inhibit expression of CD59 in tumors lacking the full-length REST and proposed a detailed model for regulation of CD59 expression via interplay between REST and nu...
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تاریخ انتشار 2010